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Comparison between the first and second generation bioresorbable vascular scaffolds: a six month virtual histology study

Identifieur interne : 006C46 ( Main/Exploration ); précédent : 006C45; suivant : 006C47

Comparison between the first and second generation bioresorbable vascular scaffolds: a six month virtual histology study

Auteurs : Salvatore Brugaletta [Pays-Bas] ; Hector M. Garcia-Garcia [Pays-Bas] ; Roberto Biletti [Pays-Bas] ; Josep Cornez- Lara [Pays-Bas] ; Scot Garg [Pays-Bas] ; Yoshinobu Onuma [Pays-Bas] ; Eun-Seok Shin [Pays-Bas] ; Robert Jan Van Geuns [Pays-Bas] ; Bernard De Bruyne [Belgique] ; Dariusz Dudek [Pologne] ; Leif Thuesen [Danemark] ; Bernard Chevalier [France] ; Dougal Mcclean [Nouvelle-Zélande] ; Stephan Windecker [Suisse] ; Robert Whitbourn [Australie] ; Cecile Dorange [Belgique] ; Susan Veldhof [Belgique] ; Richard Rapoza [États-Unis] ; Krishnankutty Sudhir [États-Unis] ; Nico Bruining [Pays-Bas] ; John A. Ormiston [Pays-Bas] ; Patrick W. Serruys [Pays-Bas]

Source :

RBID : Pascal:11-0198545

Descripteurs français

English descriptors

Abstract

Aims: To compare the intravascular ultrasound virtual histology (IVUS-VH) appearance of the polymeric struts of the first (Revision 1.0) and the second (Revision 1.1) generation bioresorbable vascular scaffold (BVS). Methods and results: IVUS-VH misrepresents polymeric struts as dense calcium (DC) and necrotic core (NC) so that their presence and disappearance could be used as potential artifactual surrogate of bioresorption. DC and NC were assessed in both revisions of the BVS by analysing IVUS-VH from all patients in the ABSORB cohort A (Revision 1.0) and cohort B (Revision 1.1) study who had an IVUS-VH post-treatment and at 6-month follow-up. Post-treatment and 6-month follow-up IVUS-VH results, available in 60 patients (BVS 1.0 n=28; BVS 1.1 n=32), indicated an insignificant rise in DC+NC area compared to baseline with Revision 1.1 (0.10±0.46mm2, p=0.2), whilst a significant reduction was seen with Revision 1.0 (-0.57±1.3 mm2, p=0.02). A significant correlation has been found between the change in the DC+NC area and the change in external elastic membrane area (y=0.68×-0.1; r=0.58, p=0.03). Conclusions: Based on 6-months IVUS-VH analysis, the BVS 1.1 appears to have a different backscattering signal compared to the BVS 1.0, which may reflect differences in the speed of chemical and structural alteration.


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Le document en format XML

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<title xml:lang="en" level="a">Comparison between the first and second generation bioresorbable vascular scaffolds: a six month virtual histology study</title>
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<settlement type="city">Rotterdam</settlement>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<name sortKey="De Bruyne, Bernard" sort="De Bruyne, Bernard" uniqKey="De Bruyne B" first="Bernard" last="De Bruyne">Bernard De Bruyne</name>
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<s3>BEL</s3>
<sZ>9 aut.</sZ>
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<country>Belgique</country>
<wicri:noRegion>Cardiovascular Center Aalst</wicri:noRegion>
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<author>
<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
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<sZ>10 aut.</sZ>
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<country>Pologne</country>
<wicri:noRegion>Krakow</wicri:noRegion>
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<sZ>11 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Skejby</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chevalier, Bernard" sort="Chevalier, Bernard" uniqKey="Chevalier B" first="Bernard" last="Chevalier">Bernard Chevalier</name>
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<s2>Massy</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Massy</wicri:noRegion>
<wicri:noRegion>Institute Hasp. Jacques Cartier</wicri:noRegion>
<wicri:noRegion>Massy</wicri:noRegion>
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<author>
<name sortKey="Mcclean, Dougal" sort="Mcclean, Dougal" uniqKey="Mcclean D" first="Dougal" last="Mcclean">Dougal Mcclean</name>
<affiliation wicri:level="1">
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<s1>Department of Cardiology, Christchurch Hospitat</s1>
<s2>Christchurch</s2>
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<sZ>13 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Christchurch</wicri:noRegion>
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<name sortKey="Windecker, Stephan" sort="Windecker, Stephan" uniqKey="Windecker S" first="Stephan" last="Windecker">Stephan Windecker</name>
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<country>Suisse</country>
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<country>Australie</country>
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<name sortKey="Veldhof, Susan" sort="Veldhof, Susan" uniqKey="Veldhof S" first="Susan" last="Veldhof">Susan Veldhof</name>
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<country>Belgique</country>
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<country>États-Unis</country>
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<name sortKey="Sudhir, Krishnankutty" sort="Sudhir, Krishnankutty" uniqKey="Sudhir K" first="Krishnankutty" last="Sudhir">Krishnankutty Sudhir</name>
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<country>États-Unis</country>
<wicri:noRegion>Abbott Vascular</wicri:noRegion>
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<name sortKey="Bruining, Nico" sort="Bruining, Nico" uniqKey="Bruining N" first="Nico" last="Bruining">Nico Bruining</name>
<affiliation wicri:level="3">
<inist:fA14 i1="01">
<s1>Thoraxcenter, Erasmus MC</s1>
<s2>Rotterdam</s2>
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<country>Pays-Bas</country>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ormiston, John A" sort="Ormiston, John A" uniqKey="Ormiston J" first="John A." last="Ormiston">John A. Ormiston</name>
<affiliation wicri:level="3">
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<country>Pays-Bas</country>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Serruys, Patrick W" sort="Serruys, Patrick W" uniqKey="Serruys P" first="Patrick W." last="Serruys">Patrick W. Serruys</name>
<affiliation wicri:level="3">
<inist:fA14 i1="01">
<s1>Thoraxcenter, Erasmus MC</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
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<country>Pays-Bas</country>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">EuroIntervention</title>
<title level="j" type="abbreviated">EuroIntervention</title>
<idno type="ISSN">1774-024X</idno>
<imprint>
<date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">EuroIntervention</title>
<title level="j" type="abbreviated">EuroIntervention</title>
<idno type="ISSN">1774-024X</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Blood vessel</term>
<term>Comparative study</term>
<term>Generation</term>
<term>Histology</term>
<term>Sonography</term>
<term>Ultrasound</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Etude comparative</term>
<term>Génération</term>
<term>Vaisseau sanguin</term>
<term>Histologie</term>
<term>Ultrason</term>
<term>Exploration ultrason</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Histologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Aims: To compare the intravascular ultrasound virtual histology (IVUS-VH) appearance of the polymeric struts of the first (Revision 1.0) and the second (Revision 1.1) generation bioresorbable vascular scaffold (BVS). Methods and results: IVUS-VH misrepresents polymeric struts as dense calcium (DC) and necrotic core (NC) so that their presence and disappearance could be used as potential artifactual surrogate of bioresorption. DC and NC were assessed in both revisions of the BVS by analysing IVUS-VH from all patients in the ABSORB cohort A (Revision 1.0) and cohort B (Revision 1.1) study who had an IVUS-VH post-treatment and at 6-month follow-up. Post-treatment and 6-month follow-up IVUS-VH results, available in 60 patients (BVS 1.0 n=28
<sub>;</sub>
BVS 1.1 n=32), indicated an insignificant rise in DC+NC area compared to baseline with Revision 1.1 (0.10±0.46mm
<sup>2</sup>
, p=0.2), whilst a significant reduction was seen with Revision 1.0 (-0.57±1.3 mm
<sup>2</sup>
, p=0.02). A significant correlation has been found between the change in the DC+NC area and the change in external elastic membrane area (y=0.68×-0.1; r=0.58, p=0.03). Conclusions: Based on 6-months IVUS-VH analysis, the BVS 1.1 appears to have a different backscattering signal compared to the BVS 1.0, which may reflect differences in the speed of chemical and structural alteration.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region>
<li>Hollande-Méridionale</li>
</region>
<settlement>
<li>Rotterdam</li>
</settlement>
</list>
<tree>
<country name="Pays-Bas">
<region name="Hollande-Méridionale">
<name sortKey="Brugaletta, Salvatore" sort="Brugaletta, Salvatore" uniqKey="Brugaletta S" first="Salvatore" last="Brugaletta">Salvatore Brugaletta</name>
</region>
<name sortKey="Biletti, Roberto" sort="Biletti, Roberto" uniqKey="Biletti R" first="Roberto" last="Biletti">Roberto Biletti</name>
<name sortKey="Bruining, Nico" sort="Bruining, Nico" uniqKey="Bruining N" first="Nico" last="Bruining">Nico Bruining</name>
<name sortKey="Cornez Lara, Josep" sort="Cornez Lara, Josep" uniqKey="Cornez Lara J" first="Josep" last="Cornez- Lara">Josep Cornez- Lara</name>
<name sortKey="Garcia Garcia, Hector M" sort="Garcia Garcia, Hector M" uniqKey="Garcia Garcia H" first="Hector M." last="Garcia-Garcia">Hector M. Garcia-Garcia</name>
<name sortKey="Garg, Scot" sort="Garg, Scot" uniqKey="Garg S" first="Scot" last="Garg">Scot Garg</name>
<name sortKey="Jan Van Geuns, Robert" sort="Jan Van Geuns, Robert" uniqKey="Jan Van Geuns R" first="Robert" last="Jan Van Geuns">Robert Jan Van Geuns</name>
<name sortKey="Onuma, Yoshinobu" sort="Onuma, Yoshinobu" uniqKey="Onuma Y" first="Yoshinobu" last="Onuma">Yoshinobu Onuma</name>
<name sortKey="Ormiston, John A" sort="Ormiston, John A" uniqKey="Ormiston J" first="John A." last="Ormiston">John A. Ormiston</name>
<name sortKey="Serruys, Patrick W" sort="Serruys, Patrick W" uniqKey="Serruys P" first="Patrick W." last="Serruys">Patrick W. Serruys</name>
<name sortKey="Shin, Eun Seok" sort="Shin, Eun Seok" uniqKey="Shin E" first="Eun-Seok" last="Shin">Eun-Seok Shin</name>
</country>
<country name="Belgique">
<noRegion>
<name sortKey="De Bruyne, Bernard" sort="De Bruyne, Bernard" uniqKey="De Bruyne B" first="Bernard" last="De Bruyne">Bernard De Bruyne</name>
</noRegion>
<name sortKey="Dorange, Cecile" sort="Dorange, Cecile" uniqKey="Dorange C" first="Cecile" last="Dorange">Cecile Dorange</name>
<name sortKey="Veldhof, Susan" sort="Veldhof, Susan" uniqKey="Veldhof S" first="Susan" last="Veldhof">Susan Veldhof</name>
</country>
<country name="Pologne">
<noRegion>
<name sortKey="Dudek, Dariusz" sort="Dudek, Dariusz" uniqKey="Dudek D" first="Dariusz" last="Dudek">Dariusz Dudek</name>
</noRegion>
</country>
<country name="Danemark">
<noRegion>
<name sortKey="Thuesen, Leif" sort="Thuesen, Leif" uniqKey="Thuesen L" first="Leif" last="Thuesen">Leif Thuesen</name>
</noRegion>
</country>
<country name="France">
<noRegion>
<name sortKey="Chevalier, Bernard" sort="Chevalier, Bernard" uniqKey="Chevalier B" first="Bernard" last="Chevalier">Bernard Chevalier</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande">
<noRegion>
<name sortKey="Mcclean, Dougal" sort="Mcclean, Dougal" uniqKey="Mcclean D" first="Dougal" last="Mcclean">Dougal Mcclean</name>
</noRegion>
</country>
<country name="Suisse">
<noRegion>
<name sortKey="Windecker, Stephan" sort="Windecker, Stephan" uniqKey="Windecker S" first="Stephan" last="Windecker">Stephan Windecker</name>
</noRegion>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Whitbourn, Robert" sort="Whitbourn, Robert" uniqKey="Whitbourn R" first="Robert" last="Whitbourn">Robert Whitbourn</name>
</noRegion>
</country>
<country name="États-Unis">
<noRegion>
<name sortKey="Rapoza, Richard" sort="Rapoza, Richard" uniqKey="Rapoza R" first="Richard" last="Rapoza">Richard Rapoza</name>
</noRegion>
<name sortKey="Sudhir, Krishnankutty" sort="Sudhir, Krishnankutty" uniqKey="Sudhir K" first="Krishnankutty" last="Sudhir">Krishnankutty Sudhir</name>
</country>
</tree>
</affiliations>
</record>

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